Table 2

More Query compounds and related biological activities retrieved from WENDI

Query CID

44246407

44246344

Reported activities

Inhibitor/activator of human alpha glucosidase

None

Tumor Cell Line Predictive models

50-60% probability of activity in melanoma, leukemia, otherwise <50% probability

Strong prediction (>70% probability) of activity in prostate, colon, non-small cell lung, breast, malanoma, leukemia, ovarian cancers. 50-60% probability in all other cell lines.

Bioassay activities & gene relationships of similar compounds

similar compound shows active as an inhibitor of MEK-5 Kinase 2 mutant

Similar compounds show active in NCI ovarian cancer cell line (IGROV1), breast cancer cell line (MB-435); non small cell lung cancer (H23); MLPCN Alpha-synuclein 5'UTR binding activation (Parkinson's disease); Leishmania promastigote inhibition; NCI yeast anticancer screen; RAM inhibition (STAT3);

Bioassay inactives of similar compounds

similar compounds show inactive in SIP3 antagonists assay, hERG blockers of proarrythmic agents. and 14-3-3- protein interaction modulation

similar compounds inactive in RNase H inhibition, NCI non small cell lung cancer (H23) and Leukemia (L1210); NCI yeast anticancer screen; 14-3-3 protein interaction modulators; SIP3 antagonists

CTD gene relationships of similar compounds

A similar compound associated with adenomatous polyposis

Similar compounds associated with Alzheimer's disease

Activities of similar marketed drugs

None

None

Insights from similar compounds in journal articles (MEDLINE)

None

None

Interpretation

None

None

Zhu et al. Journal of Cheminformatics 2010 2:6   doi:10.1186/1758-2946-2-6